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KMID : 0387420080190030101
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Korean Society of Oriental Neuropsychiatry
2008 Volume.19 No. 3 p.101 ~ p.115
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Experimental Study on the Antidepressant Effect of Sam-Jeong-Hwan
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Lee Sang-Taek
Kim Geun-Woo
Koo Byung-Su
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Abstract
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Objective: The purpose of this study was to investigate the protective effects of Sam-Jeong-Hwan(SJH) on the animal model of depression induced immobilization stress.
Method: The subject were divided into 4 groups(l. normal 2. saline solution administered during immobilization stress treatment 3. SJH of 100mg/kg administered 4. BKJ of 400mg/kg administered). Immobilization stress was treated for 1 hours on day. During 2 days of immobilization stress treatment, they were executed forced swimming test, passive avoidance test, elevated plus maze test. Corticosterone and ACTH in blood were measured.
Results: In forced swimming test, SJH of 400mg/kg group showed decreased immobilization. In passive avoidance test, SJH of 400mg/kg group showed increased learning execution. In EPM test, SJH of 400mg/kg group showed decreased anxiety. In locomotor activity test, SJH groups showed significantly increased locomotor activity. Stress group showed significantly increase in serum level of corticosterone, SJH of 400mg/kg group showed decreased serum level of corticosterone. Stress group showed significantly increase in serum level of ACTH, SJH of 400mg/kg group showed decreased serum level of ACTH.
Conclusion: These results suggest that Sam-Jeong-Hwan(SJH) is effective in the treatment of depression.
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KEYWORD
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Sam-Jeong-Hwan, Depression, Immobilization stress
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